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5 from 3 votes

Spaghetti Squash Pizza Casserole

This Spaghetti Squash Pizza Casserole is easy to make and true comfort food. Loaded with veggies, protein and flavor...it is going to become a dinner staple. Gluten free + veggie-loaded.
Prep Time15 mins
Cook Time27 mins
Course: Main Course
Cuisine: American
Keyword: pizza casserole recipe, spaghetti squash casserole, spaghetti squash recipe
Servings: 6
Calories: 330kcal


  • 1 medium spaghetti squash, cooked and drained see cooking suggestions and draining method above
  • 2 tsp coconut or avocado oil + extra for greasing
  • 1 pound ground chicken or turkey
  • 1/2 medium yellow onion chopped
  • 1 tsp salt or to taste
  • 2 cloves garlic minced, or to taste
  • 1 tbsp Italian seasoning
  • 2 cups mozzarella cheese divided
  • 1 1/2 cups tomato sauce I suggest looking for one with no added sugar.
  • 15-20 pepperonis I suggest using nitrate free ones.
  • fresh basil for garnish optional


  • Preheat your oven to 350℉.
  • Heat the oil in a large skillet over medium high. Add the chicken/turkey, onion, garlic and salt. Cook, breaking apart the meat, until meat is browned and the onions
    are tender. This should take about 8 minutes. Remove the meat from the heat and set aside.
  • Place drained squash into a large bowl. Add cooked meat to the bowl. Add sauce, 1 1/2 cup of cheese and Italian seasoning. Stir to combine.
  • Pour squash mixture into a lightly greased casserole dish.
  • Bake for 20 minutes. Remove from oven and top with remaining cheese and pepperoni. Return to oven and cook for 5-7 minutes or until the cheese is melted and starting to turn a golden brown.
  • Remove from oven and let cool for 5-10 minutes. Garnish with chopped basil, if desired. Enjoy warm!


Calories: 330kcal | Carbohydrates: 17g | Protein: 25g | Fat: 19g | Saturated Fat: 8g | Cholesterol: 100mg | Sodium: 1104mg | Potassium: 837mg | Fiber: 4g | Sugar: 8g | Vitamin A: 725IU | Vitamin C: 9mg | Calcium: 255mg | Iron: 2mg